Objective: To investigate the value of combined detection of human chorionic gonadotropin (HCG) and progesterone in predicting the risk of threatened abortion in early pregnancy. Methods: 92 pregnant women with suspected threatened abortion admitted to our hospital from July 2021 to March 2024 were selected as the study objects. The clinical outcome of pregnant women was analyzed and 92 pregnant women were divided into threatened abortion group and non-threatened abortion group. The general data of the two groups were analyzed and compared. The diagnostic efficacy of HCG and progesterone in the diagnosis of threatened abortion and its consistency with clinical pregnancy outcome were analyzed. Results: Among 92 patients suspected of threatened abortion, 60 cases (65.21%) of threatened abortion and 32 cases (34.78%) of non-threatened abortion. There were no significant differences in age, gestational age, BMI and gestational time between threatened abortion group and non-threatened abortion group (P>0.05). The levels of HCG and progesterone in threatened abortion group were significantly lower than those in non-threatened abortion group (P < 0.05). The sensitivity, specificity and accuracy of the combined detection of HCG and progesterone were 90.91%, 92.59% and 91.67%, respectively, which were significantly higher than the single detection of HCG and progesterone. The consistency between HCG and progesterone combined diagnosis of threatened abortion and clinical pregnancy outcome was 0.907, which was significantly higher than the consistency of HCG and progesterone single detection. Conclusion: The combined test of HCG and progesterone in early pregnancy has certain value in predicting the risk of threatened abortion. Compared with single test, the combined test can evaluate the pregnancy status more comprehensively and accurately.