Objective To investigate the value of serum Immunoglobulin A (IgA) and Immunoglobulin E (IgE) in predicting the risk of disease recurrence in children with henoch purpura. Methods 112 children with anaphylactoid purpura admitted to our hospital from January 2020 to December 2023 were selected as the study objects. Patients were divided into recurrence group (n=45) and non-recurrence group (n=67) according to whether they had relapse or not. Serum IgA and IgE levels were compared between relapsed group and non-relapsed group. Multiple Logistic regression was used to analyze the single and multiple factors affecting the recurrence of children with anaphylactoid purpura. To analyze the predictive value of serum IgA and IgE alone and combined in the recurrence of children with anaphylactoid purpura. Results The serum IgA and IgE levels in the relapsed group were significantly higher than those in the non-relapsed group (P < 0.05). Multiple Logistic regression analysis showed that family history of anaphylactoid purpura, respiratory tract infection, IgA and IgE levels were all related factors affecting the recurrence of children with anaphylactoid purpura (P < 0.05). The sensitivity, specificity and AUC (95%CI) of serum IgA and IgE combined in predicting the recurrence of children with purpura were 91.08%, 88.89% and 0.872 (0.814-0.930), respectively, which were significantly higher than the single prediction value of serum IgA and IgE. Conclusion Combined monitoring of serum IgA and IgE can more accurately reflect the changes of immune status in children with henoch purpura than a single index, and has important value in predicting the recurrence risk of henoch purpura.