Objective: To analyze the application value of root cause analysis combined with bundled nutrition intervention in postoperative patients with colon cancer. Method: A total of 100 patients with colon cancer who underwent radical resection of colon cancer in our hospital from January 2022 to December 2023 were selected as the study subjects. The patients were divided into observation group and control group by random number table method, 50 cases in each group. The control group was treated with bundled nutrition intervention; the observation group was treated with root cause analysis combined with bundled nutrition intervention. The nutrition-related indicators [prealbumin (PAB), serum albumin (ALB), and hemoglobin (Hb)], nutritional risk [nutritional risk screening 2002 (NRS2002) scale], quality of life [European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) scale] and complications were analyzed and compared between the two groups. Result: At the end of the intervention, the levels of ALB, PAB and Hb in the two groups were significantly higher than those before the intervention, and the levels of ALB, PAB and Hb in the observation group were significantly higher than those in the control group (P<0.05). At the end of the intervention, the NRS2002 scores of the two groups were significantly lower than those before the intervention, and the NRS2002 score of the observation group was significantly lower than that of the control group (P<0.05). At the end of the intervention, the scores of EORTC QLQ-C30 scale in each dimension of the two groups were significantly increased, and the scores of each dimension in the observation group were significantly higher than those in the control group (P<0.05). The incidence of complications in the observation group was significantly lower than that in the control group (P<0.05). Conclusion: The implementation of root cause analysis combined with bundled nutrition intervention in patients after colon cancer surgery can improve the nutritional level of patients, reduce the risk of malnutrition, reduce postoperative complications, and improve the quality of life of patients.