Objective: To explore the effects of three different surgical procedures on gastrointestinal function and inflammatory response in the treatment of pediatric appendiceal abscess. Method: 150 children with appendiceal abscess admitted from December 2021 to December 2023 were divided into Group A (n=45), Group B (n=54), and Group C (n=51) according to surgical methods. Open surgery, three port laparoscopic surgery, and umbilical single port laparoscopic surgery were performed respectively. The surgical indicators, postoperative intestinal function improvement, gastrointestinal function indicators [motilin (MTL), serotonin (5-HT), and gastrin (GAS)], serum inflammatory factors [C-reactive protein (CRP), interleukin-6 (IL-6), and white blood cell count (WBC)] levels of the three groups were observed and compared, and the incidence of postoperative complications was statistically analyzed. Result: The surgical time of both Group C and Group B was longer than that of Group A (P<0.05), and the surgical time of Group C was longer than that of Group B (P<0.05); The frequency of analgesic use, intraoperative bleeding, and postoperative hospital stay in Group C and Group B were lower than those in Group A (P<0.05), and the frequency of analgesic use and hospital stay in Group C were lower than those in Group B (P<0.05). Compared with Group A, Group C and Group B had shorter postoperative bowel sounds recovery time, first anal exhaust time, and first bowel movement time (P<0.05), and the above time indicators in Group C were also shorter than those in Group B (P<0.05). After surgery, the levels of MTL and GAS in Group C and Group B were higher than those in Group A (P<0.05), while the level of 5-HT was lower than that in Group A (P<0.05), and the above indicators in Group C were better than those in Group B (P<0.05). After surgery, the average levels of serum CRP and IL-6 in Group C and Group B were lower than those in the control group (P<0.05), and the WBC level was higher than that in the control group (P<0.05). Moreover, the above indicators in Group C were better than those in Group B (P<0.05). There was no significant difference in the total incidence of postoperative complications among the three groups (P>0.05). Conclusion: Compared with the other two surgical procedures, laparoscopic surgery via umbilical single port is more effective in treating pediatric appendiceal abscess, with faster recovery of intestinal function, significantly reduced inflammatory response, and lower incidence of postoperative complications.