Objective: To screen potential ferroptosis inhibitors against sepsis-associated lung injury (SALI) based on endoplasmic reticulum stress (ERS). Methods: Disease- and pathway-related targets were obtained from network pharmacology databases, and key targets were identified by constructing a protein-protein interaction network. Targeted agents corresponding to these key targets were retrieved from databases, and candidate drugs were obtained by intersecting these agents with ferroptosis inhibitors and sepsis therapeutic drugs. Molecular docking and visualization of candidate drugs and core targets were performed using the CB-Dock 2 platform and PyMOL (version 3.1.6.1) to identify potential drugs with stable binding affinity for the treatment of SALI. Results: Seven candidate drugs were screened via network pharmacology, including chloroquine, curcumin, melatonin, quercetin, resveratrol, rosiglitazone, and taurine. Molecular docking results showed that curcumin, quercetin, and rosiglitazone exhibited multi-target and high-binding-affinity characteristics, suggesting strong potential in the intervention of SALI. Conclusion: Curcumin, quercetin, and rosiglitazone possess the potential to target and regulate the ERS-ferroptosis axis against sepsis-associated lung injury.