Objective: To analyze the correlation between serum C-reactive protein (CRP) binding to neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) and airway hyperresponsiveness in children with bronchopneumonia. Methods: A total of 66 children with bronchopneumonia who received treatment in our hospital from January 2023 to December 2024 were selected. Basic patient data was collected, and the children were divided into an airway hyperresponsiveness group and a normal group based on whether they experienced airway hyperresponsiveness. The serum CRP levels, NLR, and PLR of the two groups were compared, and a multivariate logistic regression model and Spearman correlation analysis were used to investigate the relationship and correlation between serum CRP, NLR, PLR, and airway hyperresponsiveness in children with bronchopneumonia. Results: After evaluation, it was found that 36 out of 66 children developed airway hyperresponsiveness, accounting for 54.55%, while 30 cases (45.45%) did not develop airway hyperresponsiveness. The serum levels of CRP, NLR, and PLR in children with airway hyperresponsiveness were significantly higher than those in the normal group, and the difference was statistically significant (P<0.05). The results of multivariate logistic analysis showed that high levels of serum CRP, NLR, and PLR in children were risk factors for airway hyperresponsiveness (P<0.05). Spearman correlation analysis found that the levels of serum CRP, NLR, and PLR in children with bronchopneumonia were negatively correlated with the occurrence of airway hyperresponsiveness (P<0.05). Conclusion: The levels of serum CRP, NLR, and PLR in children with bronchopneumonia are closely related to whether they develop airway hyperresponsiveness. Clinical attention should be paid to such children, and timely assessment of whether they develop airway hyperresponsiveness can provide a certain basis for adjusting clinical medication and treatment plans.