Objective Analysis of the complete genomic characteristics of the virus causing a local outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Deyang City in October 2022, providing a reference for precise epidemic prevention and control. Methods: Positive specimens of COVID-19 patients from this local epidemic were collected. Whole-genome sequencing of the novel coronavirus was performed using high-throughput second-generation sequencing technology, and sequence assembly and splicing were conducted using the "MicronCov" genomic sequencing analysis platform. The strain and specific type of the virus were analyzed using the Nextclade and Pangolin online platforms. Multiple sequence alignment was performed using MAFFT (v.7.037b), and a phylogenetic tree of the virus was constructed using the evolutionary analysis software MEGA 7. Tracing analysis was conducted in combination with epidemiological investigation information. Results: Eight high-quality sequences (coverage > 96%) were obtained through sequencing. The Nextclade typing results were all 22B Omicron, and the Pangolin typing results were all BA.5.2.48 variant strains. Compared with the Wuhan reference strain (EPI_ISL_402124), the 8 BA.5.2.48 sequences had 75-77 nucleotide mutation sites. Among them, 4 sequences shared 75 nucleotide mutation sites. In the other 4 sequences, there were mutations of A14960T and T15521A in the NSP12 region and a reversion mutation of A12160G; as well as a T22304A mutation in the NTD region of the S protein. The phylogenetic tree showed that the 8 specimens from two different areas of Deyang City were located under one evolutionary branch and clustered with the sequences of cases from Guangdong, Beijing, and Tianjin during the same period. Conclusion: The BA.5.2.48 variant strain of Omicron caused this local epidemic. Before the first reported case, it had been spreading covertly in the local area. The local novel coronavirus continues to mutate, and it is necessary to continuously strengthen the monitoring of local novel coronavirus mutations.